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Optimizing Treatment Selection for Opioid Use Disorder: Tailoring MAT Strategies to Improve Patient Outcomes

: Internet Activity
: 1.0 AMA PRA Category 1 Credit™
Target Audience
: Physicians, PAs, Nurse practitioners
Expiration Date
: 11/05/2016

Read the content below to launch the activity

Learning Objectives

After completing this activity, the participant will demonstrate the ability to:

  1. Describe the different agents that act on the mu opioid receptor in the brain-reward pathway, and how differences in their mechanism of action translate into clinical use
  2. Review factors that facilitate or hinder adherence to opioid use disorder (OUD) treatment and assess patient readiness for changing behavior related to aberrant opioid use
  3. Compare the efficacy, safety, and clinical rationale of the different FDA-approved pharmacotherapies for the treatment of OUD
  4. Evaluate evidence-based treatment-matching strategies for OUD and approaches to overcoming barriers to treatment adherence



Roger D. Weiss, MD, Chair
Professor of Psychiatry
Harvard Medical School
Chief, Division of Alcohol and Drug Abuse
McLean Hospital
Belmont, MA


R. Kathryn McHugh, PhD
Assistant Professor, Department of Psychiatry
Harvard Medical School
Associate Psychologist
Division of Alcohol and Drug Abuse
McLean Hospital
Belmont, MA


Charles P. O'Brien, MD, PhD
Kenneth Appel Professor
Department of Psychiatry
University of Pennsylvania
Philadelphia, PA


Statement of Need:             
Opioid use disorder (OUD) is a prevalent and serious psychiatric illness with severe consequences, including death, if left untreated. Despite the availability of evidence-based treatment guidelines and medications that aid in the withdrawal from opioids and in long-term maintenance, OUD continues to be underdiagnosed and undertreated. Recent studies indicate that clinicians treating OUD lack understanding about the mechanisms of action of available medications to treat OUD, and how medication choice can influence patient adherence to treatment and clinical outcomes. The scenarios that follow describe and illustrate patient and disease-related considerations in medication-assisted treatment of OUD.

Physician Accreditation Statement:               
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Global Education Group (Global) and HealthmattersCME. Global is accredited by the ACCME to provide continuing medical education (CME) for physicians.
Physician Credit Designation:           
Global Education Group designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Psychology Accreditation Statement:            
Global Education Group (Global) is approved by the American Psychological Association (APA) to sponsor continuing education for psychologists. Global maintains responsibility for this program and its content. This activity has been approved for a maximum of 1.0 CE credits for psychologists. The instructional level of this activity is intermediate.
Contact Information:           
For information about the accreditation of this program, please contact Global at 303-395-1782 or
Fee Information and Refund/Cancellation Policy:       
There is no fee for this educational activity.

Disclosure of Conflicts of Interest: Global Education Group (Global) requires instructors, planners, managers, and other individuals and their spouse/life partner who are in a position to control the content of this activity to disclose any real or apparent conflict of interest (COI) they may have as related to the content of this activity. All identified COIs are thoroughly vetted by Global for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient-care recommendations.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME/CE activity:
Roger D. Weiss, MD, Chair
Consultant/Independent Contractor: Reckitt Benckiser Scientific Advisory Board
R. Kathryn McHugh, PhD                           
Nothing to disclose

Charles P. O'Brien, MD, PhD             
Consultant/Independent Contractor: Embera NeuroTherapeutics, Inc.
The planners and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME/CE activity:
Andrea Funk                                         
Nothing to disclose

Amanda Glazar, PhD                            
Nothing to disclose

James Murphy                                      
Nothing to disclose

Disclosure of Unlabeled Use:
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group (Global) and HealthmattersCME do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities.
Instructions for Receiving Credit:   
In order to receive credit for this activity, the participant must review the content, complete the post-test with a passing score of 70% or higher, and complete the evaluation form.
This activity is jointly provided by Global Education Group and HealthmattersCME.
This activity is supported by an independent educational grant from Alkermes.


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Google Chrome 28.0+ for Windows, Mac OS, or Linux
Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux
Safari 6+ for Mac OSX 10.7 and above

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